Our aims are to identify the key targets of immunity, understand the mechanisms mediating immunity, and determine how immunity is acquired and maintained.

This involves combining detailed studies of immune responses with clinical and population studies of children and pregnant women in Papua New Guinea, Kenya, Malawi, and the Thailand-Myanmar (Burma) border region.

Studies focus on understanding how antibodies neutralise and clear malaria parasites in the blood (for both P. falciparum and P. vivax ), and understanding the importance of interactions with monocytes/macrophages and other immune cells.

As part of these studies, we are also aiming to develop strategies to use serology as a cost tool to estimate the malaria burden in populations, identify changes in malaria transmission over time, and evaluate the impact of malaria control interventions on the burden of malaria.