Protein trafficking and host remodelling is essential for the malaria parasite to survive in its host cells.
My project aims to address this issue by identifying the molecular basis of how translocon of exported proteins (PTEX) selectively transport parasite proteins to host red cells.
Further investigation on the biological significance of this molecular recognition process might help us in finding new drugs for killing the parasite.
2016 : BSc (Hons), Institut Teknologi Bandung, Indonesia.
- The Plasmodium falciparum parasitophorous vacuole protein P113 interacts with the parasite protein export machinery and maintains normal vacuole architecture.
Bullen HE, Sanders PR, Dans MG, Jonsdottir TK, Riglar DT, Looker O, Palmer CS, Kouskousis B, Charnaud SC, Triglia T, Gabriela M, Schneider MP, Chan JA, de Koning-Ward TF, Baum J, Kazura JW, Beeson JG, Cowman AF, Gilson PR, Crabb BS
Mol Microbiol. 2022 Apr; Epub ahead of print
- A revised mechanism for how Plasmodium falciparum recruits and exports proteins into its erythrocytic host cell.
Gabriela M, Matthews KM, Boshoven C, Kouskousis B, Jonsdottir TK, Bullen HE, Modak J, Steer DL, Sleebs BE, Crabb BS, Koning-Ward TF, Gilson PR
PLoS Pathog. 2022 Feb; 18(2):e1009977
- The role of malaria parasite heat shock proteins in protein trafficking and remodelling of red blood cells.
Jonsdottir TK, Gabriela M, Gilson PR
Adv Exp Med Biol. 2021 Sep; 1340:141-167
- Defining the Essential Exportome of the Malaria Parasite.
Jonsdottir TK, Gabriela M, Crabb BS, F de Koning-Ward T, Gilson PR
Trends Parasitol. 2021 May; 37(7):664-675
- Characterisation of complexes formed by parasite proteins exported into the host cell compartment of Plasmodium falciparum infected red blood cells.
Jonsdottir TK, Counihan NA, Modak JK, Kouskousis B, Sanders PR, Gabriela M, Bullen HE, Crabb BS, de Koning-Ward TF, Gilson PR
Cell Microbiol. 2021 Mar; 23(8):e13332
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