Background

KEY PROJECTS:

• Human malaria pathogenesis, both in children and in pregnant women
• Mechanisms of adhesion of malaria-infected erythrocytes to placental tissue
• Impact of malaria infection on placental functions
• Mechanisms of fetal growth restriction in malaria in pregnancy
• Maternal nutrition and immunity to malaria in pregnancy

COLLABORATIONS:
National collaborations

• University of Melbourne: Professor Stephen Rogerson
• Monash University: Professor Rod Devenish
• Australian National University: A/Prof Alexander Maier

European collaborations

• IRD, Paris, France: Professor Philippe Deloron, Professor Michel Cot and Dr Valerie Briand
• Inserm/Université de Lille, France: Professor Damien Subtil
• Centre for Medical Parasitology, Copenhagen: Professor Ali Salanti, Professor Lars Hviid, A/Prof Lea Barfod
• University of Manchester: Dr Jocelyn Glazier

International (non-European) collaborations

• University of Denver, Colorado: Professor Thomas Jansson
• University of Abomey-Calavi, Benin: Professor Achille Massougbod

Appointments

• 2012 – present: Australian Society for Medical Research (ASMR)
• 2010 – present: Victorian Infection and Immunity Network
• 2010 – present: Australian Society for Parasitology
• 2010 – present: Australian and New Zealand Placental Research Association (ANZPRA)
• 2008 – present: The American Association for the Advancement of Science (AAAS)
• 2006 – present: International Federation of Placenta Association (IFPA)
• 2005 – present: ARC/NHMRC Research Network for Parasitology
• 1999 – 2000: British Society for Parasitology

Positions

• 2005 – 2014: Senior Research Fellow, Department of Medicine, The University of Melbourne
• 2005: Post-doctoral fellow, Pasteur Institute, Paris

Qualifications

• 2005: PhD in Immunology, Institut Pasteur, Paris, France
• 2000: Honours in Parasitology, University of Lille I and Montpellier II, Institut Pasteur, Paris
• 1999: Bachelor in Cellular Biology and Physiology, University of Paris VI and University of Manchester

Awards

• 2014: Travel Award, Australian/European Malaria Research Network (OzEMalaR)
• 2013: Dyason Fellowship, University of Melbourne
• 2012: Travel Award, Australian/European Malaria Research Network (OzEMalaR)
• 2011: Travel Award, Australian/European Malaria Research Network (OzEMalaR)
• 2011: Bursary from the Australian Academy of Science “Australia-France Symposium: Showcasing Excellence in Biomedical Research”, Canberra
• 2010: ASP ECR Prize, 12th International Congress of Parasitology, Melbourne
• 2007: Fellowship, ARC/NHMRC Research Network for Parasitology

Projects (4)

Current (4)

• Burnet Microbiome Initiative
  Pilot study to characterise the vaginal microbiome in women from the HMHB cohort.
• Healthy Mothers, Healthy Babies
  A collaborative research program aimed at providing life-saving health care for women and children in PNG.
• HMHB: The impact of nutrition, malaria and STIs on pregnant women and infants
  Determining the major preventable causes of poor maternal health and low birth weight of babies in PNG.
• HS-RDT MiP: Clinical Performance of HRP2 Rapid Diagnostic Test for Malaria Diagnosis in Pregnant Women in PNG
  This project will compare the performance of novel high sensitivity Plasmodium falciparum rapid diagnostic tests with conventional malaria rapid diagnostic tests in pregnant women in Papua New Guinea

Publications (28)

2018 (1)

• Combating low birth weight due to malaria infection in pregnancy.
  Beeson JG, Scoullar MJL, Boeuf P
  Sci Transl Med. 2018 Mar; 10(431):eaat1506

2017 (3)

• Impaired placental autophagy in placental malaria.
  Dimasuay KG, Gong L, Rosario F, McBryde E, Spelman T, Glazier J, Rogerson SJ, Beeson JG, Jansson T, Devenish RJ, Boeuf P
  PLoS One. 2017 Nov; 12(11):e0187291
• Declining malaria transmission differentially impacts on the maintenance of humoral immunity to Plasmodium falciparum in children.
  Mugyenyi CK, Elliott SR, Yap XZ, Feng G, Boeuf P, Fegan G, Osier FFH, Fowkes FJI, Avril M, Williams TN, Marsh K, Beeson JG
  J Infect Dis. 2017 Oct; 216(7):887-898
• Inhibition of placental mTOR signaling provides a link between placental malaria and reduced birthweight.
  Dimasuay KG, Aitken EH, Rosario F, Njie M, Glazier J, Rogerson SJ, Fowkes FJ, Beeson JG, Powell T, Jansson T, Boeuf P
  BMC Med. 2017 Jan; 15(1):1

2016 (6)

• The global threat of Zika virus to pregnancy: epidemiology, clinical perspectives, mechanisms, and impact.
  Boeuf P, Drummer HE, Richards JS, Scoullar MJ, Beeson JG
  BMC Med. 2016 Aug; 14(1):112
• IFPA meeting 2015 workshop report IV: Placenta and obesity; stem cells of the feto-maternal interface; placental immunobiology and infection.
  Abumaree MH, Almutairi A, Cash S, Boeuf P, Chamley LW, Gamage T, James JL, Kalionis B, Khong TY, Kolahi KS, Lim R, Liong S, Morgan TK, Motomura K, Peiris HN, Pelekanos RA, Pelzer E, Shafiee A, Lash GE, Natale D
  Placenta. 2016 Aug; 48(Suppl. 1):S17-S20
• The ins and outs of phosphosignalling in Plasmodium: parasite regulation and host cell manipulation.
  Carvalho TG, Morahan B, von Freyend SJ, Boeuf P, Grau G, Bustos JG, Doerig C
  Mol Biochem Parasitol. 2016 May; 208(1):2-15
• Placental Responses to Changes in the Maternal Environment Determine Fetal Growth.
  Dimasuay KG, Boeuf P, Powell TL, Jansson T
  Front Physiol. 2016 Jan; 7:12
• Immunity to malaria in an era of declining malaria transmission.
  Fowkes FJ, Boeuf P, Beeson JG
  Parasitology. 2016 Jan; 143(2):139-153
• Pathogenesis of Malarial Parasites in Humans (Book Chapter)
  Caroline Lin Lin Chua, Ricardo Ataíde, Alexandra J. Umbers, and Phillipe Boeuf
  In: Human Emerging and Re-emerging Infections Set. Sunit K. Singh (Editor) Wiley-Blackwell. 2016 Jan; Chapter 21:399-422

2015 (4)

• Azithromycin-containing intermittent preventive treatment in pregnancy affects gestational weight gain, an important predictor of birthweight in Papua New Guinea - an exploratory analysis.
  Holger W Unger, Regina A Wangnapi, Maria Ome-Kaius, Philippe Boeuf, Stephan Karl, Ivo Mueller, Stephen J Rogerson
  Matern Child Nutr. 2015 Sep; Epub ahead of print
• A Robust Phagocytosis Assay to Evaluate the Opsonic Activity of Antibodies against Plasmodium falciparum-Infected Erythrocytes.
  Teo A, Hasang W, Boeuf P, Rogerson S
  Methods Mol Biol. 2015 Jul; 1325:145-152
• Maximizing antimalarial efficacy and the importance of dosing strategies.
  Beeson JG, Boeuf P, Fowkes FJ
  BMC Med. 2015 May; 13(1):110
• High numbers of circulating pigmented polymorphonuclear neutrophils as a prognostic marker for decreased birth weight during malaria in pregnancy.
  Caroline Lin Lin Chua, Leanne J Robinson, Francesca Baiwog, Danielle I Stanisic, John A Hamilton, Graham V Brown, Stephen J Rogerson, Philippe Boeuf
  Int J Parasitol. 2015 Feb; 45(2-3):107-111

2014 (2)

• Insight into the pathogenesis of fetal growth restriction in placental malaria: decreased placental glucose transporter isoform 1 expression.
  Upeksha P Chandrasiri, Caroline L L Chua, Alexandra J Umbers, Ebbie Chaluluka, Jocelyn D Glazier, Stephen J Rogerson, Philippe Boeuf
  J Infect Dis. 2014 May; 209(10):1663-1667
• Utilizing nanobody technology to target non-immunodominant domains of VAR2CSA.
  Sisse B Ditlev, Raluca Florea, Morten A Nielsen, Thor G Theander, Stefan Magez, Philippe Boeuf, Ali Salanti
  PLoS One. 2014 Jan; 9(1):e84981

2013 (4)

• Soluble CD163, a product of monocyte/macrophage activation, is inversely associated with haemoglobin levels in placental malaria.
  Caroline Lin Lin Chua, Graham V Brown, John A Hamilton, Malcolm E Molyneux, Stephen J Rogerson, Philippe Boeuf
  PLoS One. 2013 May; 8(5):e64127
• IFPA Meeting 2012 Workshop Report II: epigenetics and imprinting in the placenta, growth factors and villous trophoblast differentiation, role of the placenta in regulating fetal exposure to xenobiotics during pregnancy, infection and the placenta.
  M S Ahmed, L M Aleksunes, P Boeuf, M K Chung, G Daoud, G Desoye, P Diaz, T G Golos, N P Illsley, K Kikuchi, R Komatsu, T Lao, D M Morales-Prieto, T Nanovskaya, T Nobuzane, C T Roberts, R Saffery, I Tamura, K Tamura, N G Than, M Tomi, A Umbers, B Wang, M S Weedon-Fekjaer, S Yamada, K Yamazaki, M Yoshie, G E Lash
  Placenta. 2013 Mar; 34 Suppl:S6-10
• Plasmodium falciparum malaria elicits inflammatory responses that dysregulate placental amino acid transport.
  Philippe Boeuf, Elizabeth H Aitken, Upeksha Chandrasiri, Caroline Lin Lin Chua, Bernie McInerney, Leon McQuade, Michael Duffy, Malcolm Molyneux, Graham Brown, Jocelyn Glazier, Stephen J Rogerson
  PLoS Pathog. 2013 Feb; 9(2):e1003153
• Monocytes and macrophages in malaria: protection or pathology?
  Caroline Lin Lin Chua, Graham Brown, John A Hamilton, Stephen Rogerson, Philippe Boeuf
  Trends Parasitol. 2013 Jan; 29(1):26-34

2012 (1)

• Insights into deregulated TNF and IL-10 production in malaria: implications for understanding severe malarial anaemia.
  Philippe S Boeuf, Severine Loizon, Gordon A Awandare, John K A Tetteh, Michael M Addae, George O Adjei, Bamenla Goka, Jorgen A L Kurtzhals, Odile Puijalon, Lars Hviid, Bartholomew D Akanmori, Charlotte Behr
  Malar J. 2012 Aug; 11:253

2011 (2)

• Relevant assay to study the adhesion of Plasmodium falciparum-infected erythrocytes to the placental epithelium.
  Philippe Boeuf, Wina Hasang, Eric Hanssen, Jocelyn D Glazier, Stephen J Rogerson
  PLoS One. 2011 Jun; 6(6):e21126
• Placental malaria-associated inflammation disturbs the insulin-like growth factor axis of fetal growth regulation.
  Alexandra J Umbers, Philippe Boeuf, Caroline Clapham, Danielle I Stanisic, Francesca Baiwog, Ivo Mueller, Peter Siba, Christopher L King, James G Beeson, Jocelyn Glazier, Stephen J Rogerson
  J Infect Dis. 2011 Feb; 203(4):561-569

2008 (1)

• Placental hypoxia during placental malaria.
  Philippe Boeuf, Aimee Tan, Cleofe Romagosa, Jane Radford, Victor Mwapasa, Malcolm E Molyneux, Steven R Meshnick, Nicholas H Hunt, Stephen J Rogerson
  J Infect Dis. 2008 Mar; 197(5):757-765

2007 (2)

• V beta profiles in African children with acute cerebral or uncomplicated malaria: very focused changes among a remarkable global stability.
  Severine Loizon, Philippe Boeuf, John K A Tetteh, Bamenla Goka, George Obeng-Adjei, Jorgen A L Kurtzhals, Christophe Rogier, Bartholomew D Akanmori, Odile Mercereau-Puijalon, Lars Hviid, Charlotte Behr
  Microbes Infect. 2007 Sep; 9(11):1252-1259
• New approaches to pathogenesis of malaria in pregnancy.
  S J Rogerson, P Boeuf
  Parasitology. 2007 Jul; 134(Pt 13):1883-1893

2006 (1)

• Increased levels of inflammatory mediators in children with severe Plasmodium falciparum malaria with respiratory distress.
  Gordon A Awandare, Bamenla Goka, Philippe Boeuf, John K A Tetteh, Jorgen A L Kurtzhals, Charlotte Behr, Bartholomew D Akanmori
  J Infect Dis. 2006 Nov; 194(10):1438-1446

2005 (1)

• CyProQuant-PCR: a real time RT-PCR technique for profiling human cytokines, based on external RNA standards, readily automatable for clinical use.
  Philippe Boeuf, Ines Vigan-Womas, Delphine Jublot, Severine Loizon, Jean-Christophe Barale, Bartholomew Dicky Akanmori, Odile Mercereau-Puijalon, Charlotte Behr
  BMC Immunol. 2005 Mar; 6:5

News Articles (14)

2018 (6)

• Major milestone for Healthy Mothers, Healthy Babies
• Map-building workshop is streets ahead
• Baby Tessie lost her mum post-childbirth
• Putting research on the map
• Healthy Mothers, Healthy Babies: On the road with Kerryanne Tokmun
• More R&D needed in maternal and newborn health

2017 (3)

• New insights into malaria immunity
• Malaria link to low birth weight babies identified
• Precious HMHB samples make pre-Christmas dash to Melbourne

2016 (4)

• Zika: The New Global Health Threat
• IMPACT: latest edition now out!
• Zika impact may be hidden: study
• From heartbreak to hope: A personal insight from Kokopo

2015 (1)

• Healthy Mothers, Healthy Babies lab officially opened in Kokopo