Background

Eric Gowans was previously Director, Sir Albert Sakzewski Virus Research Centre, Brisbane from 1995-2002 when he joined the Burnet Institute as a Senior Principal Research Fellow.

He is now an NHMRC Senior Research Fellow in the University of Adelaide but retains his links through an honorary appointment in the Burnet Institute.

His primary interests are in developing novel strategies for vaccines for hepatitis C virus and human immunodeficiency virus.

Bruce Loveland and Eric Gowans along with Stuart Roberts in the Gastroenterology Department at The Alfred are currently testing the efficacy of a novel therapeutic cellular vaccine to treat HCV patients who have previously failed therapy.

Publications (31)

2018 (1)

• Antibody Responses to a Quadrivalent Hepatitis C Viral-Like Particle Vaccine Adjuvanted with Toll-Like Receptor 2 Agonists.
  Christiansen D, Earnest-Silveira L, Chua B, Boo I, Drummer HE, Grubor-Bauk B, Gowans EJ, Jackson DC, Torresi J
  Viral Immunol. 2018 Feb; 31(4):338-343

2016 (1)

• A HIV-Tat/C4-binding protein chimera encoded by a DNA vaccine is highly immunogenic and contains acute EcoHIV infection in mice.
  Tomusange K, Wijesundara D, Gummow J, Garrod T, Li Y, Gray L, Churchill M, Grubor-Bauk B, Gowans EJ
  Sci Rep. 2016 Jun; 6:29131

2013 (2)

• IMGT/HighV QUEST paradigm for T cell receptor IMGT clonotype diversity and next generation repertoire immunoprofiling.
  Li S, Lefranc MP, Miles JJ, Alamyar E, Giudicelli V, Duroux P, Freeman JD, Corbin VD, Scheerlinck JP, Frohman MA, Cameron PU, Plebanski M, Loveland B, Burrows SR, Papenfuss AT, Gowans EJ
  Nat Commun. 2013 Sep; 4:2333
• Identification of specific regions in hepatitis C virus core, NS2 and NS5A that genetically interact with p7 and co-ordinate infectious virus production.
  Gouklani H, Beyer C, Drummer H, Gowans EJ, Netter HJ, Haqshenas G
  J Viral Hepat. 2013 Apr; 20(4):e66-e71

2012 (3)

• Induction of multi-functional T cells in a phase I clinical trial of dendritic cell immunotherapy in hepatitis C virus infected individuals.
  Li S, Roberts S, Plebanski M, Gouillou M, Spelman T, Latour P, Jackson D, Brown L, Sparrow R, Prince M, Hart D, Loveland BE, Gowans EJ
  PLoS One. 2012 Aug; 7(8):e39368
• Hepatitis C virus nonstructural protein 5B is involved in virus morphogenesis.
  Gouklani H, Bull RA, Beyer C, Coulibaly F, Gowans EJ, Drummer HE, Netter HJ, White PA, Haqshenas G
  J Virol. 2012 May; 86(9):5080-5088
• The dengue virus M protein localises to the endoplasmic reticulum and forms oligomers.
  Wong SS, Haqshenas G, Gowans EJ, Mackenzie J
  FEBS Lett. 2012 Apr; 586(7):1032-1037

2011 (1)

• Dengue virus PrM/M proteins fail to show pH-dependent ion channel activity in Xenopus oocytes.
  Wong SS, Chebib M, Haqshenas G, Loveland B, Gowans EJ
  Virology. 2011 Mar; 412(1):83-90

2010 (1)

• A phase I clinical trial of dendritic cell immunotherapy in HCV-infected individuals.
  Gowans EJ, Roberts S, Jones K, Dinatale I, Latour PA, Chua B, Eriksson EM, Chin R, Li S, Wall DM, Sparrow RL, Moloney J, Loudovaris M, Ffrench R, Prince HM, Hart D, Zeng W, Torresi J, Brown LE, Jackson DC
  J Hepatol. 2010 Oct; 53(4):599-607

2009 (2)

• Analysis of FOXP3+ regulatory T cells that display apparent viral antigen specificity during chronic hepatitis C virus infection.
  Li S, Floess S, Hamann A, Gaudieri S, Lucas A, Hellard M, Roberts S, Paukovic G, Plebanski M, Loveland BE, Aitken C, Barry S, Schofield L, Gowans EJ
  PLoS Pathog. 2009 Dec; 5(12):e1000707
• Surface display of IgG Fc on baculovirus vectors enhances binding to antigen-presenting cells and cell lines expressing Fc receptors.
  Martyn JC, Cardin AJ, Wines BD, Cendron A, Li S, Mackenzie J, Powell M, Gowans EJ
  Arch Virol. 2009 Jun; 154(7):1129-1138

2008 (4)

• Human dendritic cells pulsed with specific lipopeptides stimulate autologous antigen-specific T cells without the addition of exogenous maturation factors.
  Jones KL, Brown LE, Eriksson EMY, Ffrench RA, Latour PA, Loveland BE, Wall DM, Roberts SK, Jackson DC, Gowans EJ
  J Viral Hepat. 2008 Oct; 15(10):761-772
• A self-adjuvanting lipopeptide-based vaccine candidate for the treatment of hepatitis C virus infection.
  Chua BY, Eriksson EM, Brown LE, Zeng WG, Gowans EJ, Torresi J, Jackson DC
  Vaccine. 2008 Sep; 26(37):4866-4875
• Virus-specific T-cell immunity correlates with control of GB virus B infection in marmosets.
  Woollard DJ, Haqshenas G, Dong XB, Pratt BF, Kent SJ, Gowans EJ
  J Virol. 2008 Mar; 82(6):3054-3060
• Natural regulatory T cells and persistent viral infection.
  Li S, Gowans EJ, Chougnet C, Plebanski M, Dittmer U
  J Virol. 2008 Jan; 82(1):21-30

2007 (7)

• Long-term storage of DNA-free RNA for use in vaccine studies.
  Jones KL, Drane D, Gowans EJ
  Biotechniques. 2007 Nov; 43(5):675-681
• Modulation of MAPK pathways and cell cycle by replicating hepatitis B virus: factors contributing to hepatocarcinogenesis.
  Chin R, Earnest-Silveira L, Koeberlein B, Franz S, Zentgraf H, Dong X, Gowans E, Bock CT, Torresi J
  J Hepatol. 2007 Sep; 47(3):325-337
• Defining target antigens for CD25+ FOXP3 + IFN-gamma- regulatory T cells in chronic hepatitis C virus infection.
  Li S, Jones KL, Woollard DJ, Dromey J, Paukovics G, Plebanski M, Gowans EJ
  Immunol Cell Biol. 2007 Apr; 85(3):197-204
• A 2a/1b full-length p7 inter-genotypic chimeric genome of hepatitis C virus is infectious in vitro.
  Haqshenas G, Dong X, Ewart G, Bowden S, Gowans EJ
  Virology. 2007 Mar; 360(1):17-26
• A chimeric GB virus B encoding the hepatitis C virus hypervariable region 1 is infectious in vivo.
  Haqshenas G, Dong X, Netter H, Torresi J, Gowans EJ.
  J Gen Virol. 2007 Mar; 88(Pt 3):895-902
• Transient and stable expression of the HCV envelope glycoproteins in cell lines and primary hepatocytes transduced with a recombinant baculovirus.
  Martyn JC, Dong X, Holmes-Brown S, Pribul P, Li S, Drummer HE, Gowans EJ
  Arch Virol. 2007 Feb; 152(2):329-343
• Hepatitis C virus p7 protein is localized in the endoplasmic reticulum when it is encoded by a replication-competent genome.
  Haqshenas G, Mackenzie JM, Dong X, Gowans EJ
  J Gen Virol. 2007 Jan; 88(Pt 1):134-142

2006 (1)

• Amantadine inhibits the function of an ion channel encoded by GB virus B, but fails to inhibit virus replication.
  Premkumar A, Dong X, Haqshenas G, Gage PW, Gowans EJ
  Antivir Ther. 2006 Apr; 11(3):289-295

2005 (1)

• A study to investigate the impact of the initiation of highly active antiretroviral therapy on the hepatitis C virus viral load in HIV/HCV-coinfected patients.
  Mijch A, Sasadeusz J, Hellard M, Dunne M, McCaw R, Bowden S, Gowans EJ
  Antivir Ther. 2005 Jan; 10(2):277-284

2004 (3)

• Differential effects on the hepatitis C virus (HCV) internal ribosome entry site by vitamin B12 and the HCV core protein.
  Li D, Lott WB, Martyn J, Haqshenas G, Gowans EJ
  J Virol. 2004 Nov; 78(21):12075-12081
• Prospects for dendritic cell vaccination in persistent infection with hepatitis C virus.
  Gowans EJ, Jones KL, Bharadwaj M, Jackson DC
  J Clin Virol. 2004 Aug; 30(4):283-290
• Neutralising antibody, CTL and dendritic cell responses to hepatitis C virus: a preventative vaccine strategy.
  Torresi J, Bharadwaj M, Jackson DC, Gowans EJ
  Curr Drug Targets. 2004 Jan; 5(1):41-56

2003 (3)

• Immune responses in hepatitis C virus infection: the role of dendritic cells.
  Fowler NL, Torresi J, Jackson DC, Brown LE, Gowans EJ
  Immunol Cell Biol. 2003 Feb; 81(1):63-66
• Generation of CTL responses using Kunjin replicon RNA.
  Ward SM, Tindle RW, Khromykh AA, Gowans EJ
  Immunol Cell Biol. 2003 Feb; 81(1):73-78
• Maturation of dendritic cells with lipopeptides that represent vaccine candidates for hepatitis C virus.
  Chua BY, Healy A, Cameron PU, Stock O, Rizkalla M, Zeng W, Torresi J, Brown LE, Fowler NL, Gowans EJ, Jackson DC
  Immunol Cell Biol. 2003 Feb; 81(1):67-72

1990 (1)

• Effect of Phyllanthus amarus on duck hepatitis B virus replication in vivo.
  Niu JZ, Wang YY, Qiao M, Gowans E, Edwards P, Thyagarajan SP, Gust I, Locarnini S
  J Med Virol. 1990 Dec; 32(4):212-218